Differential diagnosis of smokers melanosis

Smoker's melanosis. Diffuse oral mucosal pigmentations. Smoker's melanosis Gen Dent. Mar-Apr 2010;58(2):151, 153-4. Publication types Case Reports MeSH terms Diagnosis, Differential Female Humans Melanosis / diagnosis* Middle Aged Mouth Diseases / diagnosis*. Smoker's melanosis is a brownish discoloration of the oral mucosa. The process affects most often the anterior facial gingiva of both jaws, but with a predilection for the mandible. Pipe smokers more frequently display pigmentation of the commissural and buccal mucosae. [ 5] In people who engage in reverse smoking (ie, the lit end of a.

Smoker's Melanosis Smoking may cause oral pigmentation in light-skinned individuals and accentuate the pigmentation of dark-skinned patients.18 There is increased production of melanin, which may provide a biologic defence against the noxious agents present in tobacco smoke.19 Smoker's melanosis occurs in up to 21.5% of smokers.20 The inten Smoker's melanosis is seen with the naked eye as a brown to black pigmentation of the oral tissue i.e. the gums, cheeks or palate as well as in larynx. It is most often seen in the lower labial gingiva of tobacco users. Most easily it is found in Caucasians, due to their lack of a genetically caused melanin pigmentation The microscopic appearance of melanosis is essentially similar to that seen in physiologic pigmentation or a melanotic macule. 19 Other entities to consider in differential diagnosis are racial melanosis, melanosis due to medications, Peutz-Jegher's syndrome, Addison's disease and early melanoma. Smoker's melanosis is benign and not.

Smoker׳s melanosis occurs in up to 21.5% of smokers. It is proved that the intensity of the pigmentation is related to the duration and amount of smoking,. Women are more commonly affected than men, which suggest a possible synergistic effect between the female sex hormones and smoking Smoker's dikaitkan dengan berbagai perubahan pada melanosis dapat mempengaruhi permukaan mukosa mulut. Merokok tidak hanya mukosa manapun namun pada umumnya menimbulkan efek secara sistemik, tetapi terjadi pada gingiva anterior labial juga dapat menyebabkan timbulnya kondisi mandibula, mukosa bukal, lateral lidah, dan patologis di rongga mulut Aesthetic Depigmentation of Gingival Smoker's Melanosis Using Carbon Dioxide Lasers LuisSilvaMonteiro,1,2 JoséAdrianoCosta,1 MarcoInfantedaCâmara,1 RuiAlbuquerque,3 MarcoMartins,2 JoséJúlioPacheco,1 FilomenaSalazar,1 andFernandoFigueira1,2 mucosa: presentation, differential diagnosis, and treatment,. Differential Diagnosis It is important to rule other causes before making the diagnosis of melanosis coli. Peutz-Jeghers Syndrome, an autosomal dominant disorder that leads to numerous hamartomatous polyps in the bowel with distinct findings of melanin deposition in the skin and mucosa, may look like melanosis coli

Diffuse oral mucosal pigmentations

  1. Our purpose is to summarize the actual knowledge about melanocytic lesions of the ocular surface (conjunctival nevus, primary acquired melanosis and conjunctival melanoma),especially their clinical appearance, differential diagnosis and treatment. Conjunctival nevus is the most common benign, conjun
  2. ation of the pigmentation by aesthetic reasons due to professional work issues
  3. The first step in the management of conjunctival melanosis should be differential diagnosis. Size, bilater- ality, complexion, and presence of an underlying condi- tion that causes secondary melanosis are four param- eters that help to separate PAM from nonneoplastic causes of conjunctival melanosis
  4. ation for melanoma

Differential diagnosis (1) Heavily pigmented melanoma: So-called 'animal'-type melanoma is a rare subtype of melanoma that has clinicopathological features similar to the heavily pigmented melanocytic tumours found in grey horses and other animals.It was first designated as melanosarcoma by Darier in 1925,1 but has also been called animal-type or equine-type melanoma, pigment-synthesising. Patient with melanosis of uterine cervix after cryotherapy for epithelial dysplasia (Am J Clin Pathol 1990;93:802) Gross description Flat, dark lesion up to 3 c Smoker's Melanosis. Definition : Smoker's melanosis, or smoking-associated melanosis, is a benign abnormal melanin pigmentation of the oral mucosa. Etiology : Tobacco smoke that stimulates melanocytes. Clinical features: Clinically, it appears as multiple brown pigmented areas, usually located on the anterior labial gingiva of the mandible. Malignant melanoma is the eighth most common cancer in the United States and causes 1 to 2 percent of all cancer deaths. 1, 2 Melanoma is a proliferation of transformed melanocytes or pigment. Primary acquired melanosis appears clinically as a flat and variably brown conjunctival lesion, ranging from golden brown to dark chocolate in color (Figs. 17.1 and 17.2) [].There are no published size criteria for the clinical diagnosis of PAM [], although in one large series [] PAM extended for a mean of 3 clock hours, ranging from 1 to 12 clock hours

Smoker's Melanosis Clinical Presentation: History

  1. Differential Diagnosis of Oral Pigmented Lesion 1. Full medical and dental history, the history should include the onset and duration of the lesion, the presence of associated skin hyperpigmentation the presence of systemic signs and symptoms ( e.g malaise, fatigue, weight loss) and smoking habits. SMOKER'S MELANOSIS H/O OF FILLINGS.
  2. induced pigmentation, smoker's melanosis and some syndromes can all present as a large area of pigmentation in the oral region. This case should not have been confused with racial pig-mentation, which is a physiological condition, for a number Figure 6: Differential diagnosis of pigmented lesions in the mouth, including characteristi
  3. Seborrhoeic keratoses. Dermatofibromas. Freckles. Lentigines. Pigmented basal cell carcinoma. Some other lesions may also cause diagnostic confusion, and are discussed further in the section on Features of non-melanotic lesions which can be mistaken for melanoma. These include angiomas and haemangiomas, angiokeratomas, pyogenic granulomas, and.
  4. ethepatient without discover ingthesourceofthemetastasis. This occurred in37of992patients (3.7%) Differential diagnosis of melanom

DIFFERENTIAL DIAGNOSIS OF PIGMENTED LESIONS. Pigmented Lesions • Blue • Black • Grey • Brown. Pigments • Endogenous - Hemoglobin, - Hemosiderin - Bilirubin • Minocyline Palatal Melanosis • Smoker's Melanosis • Addison's Disease • Café-au-lait Pigmentation. Racial Pigmentation. Chloasma. Putz-Jehger Syndrom Differential Diagnosis. Carcinoma; Melanoma; Anaplastic large cell lymphoma ; Epithelioid sarcoma; Alveolar and embryonal rhabdomyosarcoma; Desmoplastic small cell tumor . Carcinomas may mimic extrarenal rhabdoid tumors and in rare cases be morphologically indistinguishable. The following features favor carcinoma Age over 50 year Differential Diagnosis of Large Pigmented Lesions Many melanomas grow rapidly; dentists should be particularly cautious when confronted with a large pig-mented lesion, as in this case. Racial pigmentation, drug-induced pigmentation, smoker's melanosis and some syndromes can all present as a large area of pigmentation in the oral region

Biopsy is necessary in order to differentiate melanoacanthoma from melanoma. SMOKER'S MELANOSIS. Tobacco smoking can cause gingival pigmentation. 6 There appears to be a predilection for the mandibular anterior gingiva. Unlike heavy-metal pigmentation, which affects the free gingival margin, smoker's melanosis develops on the attached gingiva Melanosis caused by tobacco use commonly resolves on its own in 3 years after smoking cessation. The doctor may prescribe corticosteroids and topical calcineurin inhibitors if the cause is an inflammatory response. Topical retinols and retinoid treatments can help clear hyperpigmentation

91268007 - Conjunctival melanosis Look For. Subscription Required. Diagnostic Pearls. Subscription Required. Differential Diagnosis & Pitfalls. Racial melanosis - almost always bilateral; Conjunctival nevus - does not extend into cornea or fornices, may have very little pigmentation, and can have cyst Melanosis coli, also pseudomelanosis coli, is a disorder of pigmentation of the wall of the colon, often identified at the time of colonoscopy.It is benign, and may have no significant correlation with disease. The brown pigment is lipofuscin in macrophages, not melani The differential diagnosis of amelanotic nevi of the choroid includes amelanotic malignant melanoma, cavernous hemangioma of the choroid, metastatic cancer to the choroid, posterior scleritis, choroidal osteoma, and hypopigmented congenital hypertrophy of the retinal pigment epithelium. CASE REPORT. Our patient, a sixty-nine year-old Caucasian.

Smoker's melanosis - Wikipedi

  1. 3. Which test is the least invasive, yet particularly beneficial to aid with the differential diagnosis in either patient? a. Electroretinography. b. Fundus autofluorescence imaging. c. Genetic testing. d. Fluorescein angiography. 4. For the patient on the left, which is the most significant counseling you need to provide? a. Smoking cessation. b
  2. Melanosis coli. Melanosis coli is a harmless condition in which the lining of the colon and rectum, which is usually pink in color, turns a shade of black or brown
  3. Taylor's Differential Diagnosis Manual: Symptoms and Signs in the Time-Limited Encounter (Lippincott Manual Series) Part of: Lippincott Manual (16 Books) 4.6 out of 5 stars 10. Paperback. $33.66 $ 33. 66 $78.99 $78.99. Get it as soon as Tue, May 25. FREE Shipping by Amazon. Only 19 left in stock - order soon

Tobacco-Associated Lesions of the Oral Cavity: Part I

The primary goal of this course is to help you learn the process of clinical differential diagnosis of diseases and lesions of the oral mucosa. The first step in successful therapeutic management of a Heavy metal ingestion Peutz-Jeghers syndrome Neurofibromatosis Polyostotic fibrous dysplasia Pregnancy Medication Smoker's melanosis. Araki (19) states that smoker's melanosis depends on the number of cigarettes the individual smokes, and that it depends directly on the dosage. Axell (20) adds that there is more pigmentation in the first year as a smoker, and that it usually diminishes when the person stops smoking. Axell (20) also states that 21.5% of smokers have gingival. INTRODUCTION. A wide variety of lesions occurs on the vulva. Some of the disorders causing these lesions are limited to the vulva, while others also involve skin or mucocutaneous membranes elsewhere on the body. This topic provides a morphology-based classification system that can help clinicians with the differential diagnosis of these lesions. These microscopical features are very similar to those observed in idiopathic melanotic macules, in melanosis related to smoking tobacco or inflammation, in melanosis induced by certain medications, and in HIV melanosis [11, 36]. Therefore, a thorough medical history may be helpful for differential diagnosis, but the differentiation of.

Diagnosis of oral pigmentations and malignant

A wide variety of non-neoplastic conditions may be encountered on colorectal biopsy encompassing idiopathic, infectious, vascular and immune-mediated aetiologies. Although interpretation of such biopsies may be challenging, appreciation of the dominant pattern of injury and subsequent host response may allow for a more focused histological diagnosis in the correct clinical and endoscopic setting During the period 1985-1999 1154 patients were referred with a presumed melanoma and of these the diagnosis was confirmed in 936 cases (81%). In 218 patients (19%) a different final diagnosis. The method of treatment depends somewhat on the diagnosis, lesion size, morphology, and location, as well as patient compliance. If the pathology shows melanoma, reexcision is required, and lymph. The differential diagnosis of amelanotic melanoma is considered for all pyogenic granuloma, which is a common benign diagnosis presenting as a vascular nodule. Pyogenic granuloma is usually found on the fingers or toes, bleeds easily and does not readily remit. In Dermatological practice, a pyogenic granuloma would normally be surgically removed

(DOC) smoker's melanosis

  1. ocycline) — melanoplakia — pituitary Cushing's syndrome — postinflammatory pigmentation — melanoacanthoma — melanocytic nevus — blue nevus — Spitz nevu
  2. Because presentation of the two conditions can be so similar, subungual melanoma is commonly misdiagnosed with an average delay in diagnosis of 2 years. 5 This delay has a significant impact on.
  3. Immunohistochemical diagnosis of malignant melanoma of the conjunctiva and uvea: comparison of the novel antibody against melan-A with S100 protein and HMB-45. Melanoma Res . 2000 Aug. 10(4):350-4.
  4. What is the Diagnosis? Differential Diagnosis. Pigmented lesions, which are common in the mouth, may be of endogenous or exogenous origin. Oral pigmentation can be related to a wide range of factors, such as physiologic changes, foreign-body implantation, manifestations of systemic diseases and malignant neoplasms. 1,2 In the differential diagnosis, it is important to distinguish between.
  5. miRNA expression profile is distinct from other melanoma subtypes (J Invest Dermatol 2012;132:1860) Differential diagnosis Primary dermal melanoma : no in situ component, ulceration, regression or associated nevus ( Arch Dermatol 2008;144:49
  6. Differential Diagnosis • Mucosal melanotic macule • Smoking-associated melanosis • Superficial malignant melanoma Treatment • None Prognosis • Excellent 28. Etiology • Melanin pigmentation of oral mucosa in heavy smokers • May occur in up to 1 of 5 smokers
  7. Differential diagnosis. Differential diagnosis of oral melanomas are oral melanotic macule, smoking-associated melanosis, medication-induced melanosis melanocytic nevi of the oral mucosa, blue nevi, nevi of Spitz, Addisons disease, Peutz-Jeghers syndrome, amalgam tattoo and many other conditions

Differential Diagnosis. Melanoma must be differentiated from other causes of skin lesions, such as: Oral melanoma must be differentiated from other mouth lesions such as oral candidiasis and aphthous ulcer. As a side effect of medication, most commonly having taken antibiotics Differential Diagnosis. There are a number of possible causes of hoarseness, including benign laryngeal conditions, infective, neurological, malignant, and functional. Functional causes should be seen as a diagnosis of exclusion when no cause can be found, however it is a common cause for hoarseness. By Drtbalu / Public domain

Melanosis Coli Article - StatPearl

The differential diagnosis with melanoma is not easy, dermoscopy can help. Traumatized mole. In about ten days it became normal. Pigmented basalioma. It has teleangectasies ant it has peculiar dermoscopic features. Lentigo. It is symmetric and it doesn't change. Blue nevus. It looks like a melanoma, but it doesn't change If you receive a diagnosis of melanoma, the next step is to determine the extent (stage) of the cancer. To assign a stage to your melanoma, your doctor will: Determine the thickness. The thickness of a melanoma is determined by carefully examining the melanoma under a microscope and measuring it with a special tool Mucosal melanoma of the oral cavity is a rare but highly aggressive neoplasm. However, the clinicians need to be aware of the other and more frequent etiologies of intraoral pigmentation, such as amalgam tattoos. As amalgam has been extensively used for dental restorations and can cause pigmentations in the oral mucosa, this is a differential diagnosis not to be forgotten The differential diagnosis for iris lesions suspected of being melanoma should include the findings and frequency of iris pseudomelanomas reported by Shields et al: primary iris cyst (38%), iris nevus (31%), essential iris atrophy (5.7%), iris foreign body (4.5%), peripheral anterior synechia (2.5%), and iris metastasis (2.5%) Differential diagnosis of iris melanoma. A, Iris freckles are small and overlie the stroma. Multiple Lisch nodules in neurofibromatosis on a brown iris (B) and a blue iris (C). D, Congenital ocular melanocytosis is equivalent to a diffuse nevus, but is associated with pigmented patches in the episclera and sclera

[Differential diagnosis and management of melanocytic

Choroidal melanoma is a common intraocular malignancy among Caucasian adults. This serious and potentially life-threatening lesion is associated with high rates of metastasis. This teaching case report describes an otherwise healthy young patient presenting with amelanotic choroidal melanoma. Differential diagnoses, symptoms, clinical findings. melanoma, was prepared. on histopathological and immunohistochemical analysis with s-100 and homatropine methylbromide 45 the diagnosis of MM was confirmed. BaCkground Oral cavity is frequently exaggerated by various types of blue-black pigmentations like amalgam tattoo, melanotic macule, smoker's melanosis

Aesthetic Depigmentation of Gingival Smoker's Melanosis

The Differential Diagnosis of Malignant Melanoma of the Choroid: Chairman's Address. ALGERNON B. REESE, M.D.; Ira S. Jones, M.D. Author Affiliations. New York. From the Institute of Ophthalmology of the Presbyterian Hospital in the City of New York. AMA Arch Ophthalmol Primary melanoma of the lung is an extremely rare pathological entity and sparsely reported in the literature. A case of primary malignant melanoma of the lung in a 41-year-old female is reported. The clinical, radiological and histopathological features are discussed. The initial symptom was cough, whereas the chest radiography showed a round opacity of the right lung

Differential diagnosis of the conjunctival melanoses

The coexistence of lung nodules on a CT scan with worsening respiratory symptoms in the context of previous malignant melanoma would usually signify metastatic disease. The cause of the lung nodules in this 69-year-old woman turned out to be diffuse idiopathic neuroendocrine cell hyperplasia (DIPNECH) with tumourlets. DIPNECH is extremely rare, with fewer than 100 cases reported in the. Background: The purpose of the study is to evaluate the assessment of ultrasound analysis in the differential diagnosis of skin melanoma and benign cutaneous lesions.Objective: 61 patients (23 men and 38 women) between 17 and 87 years of age, with melanomas, atheromas, hemangiomas, keratoses, and naevi were studied.Methods: High-frequency gray-scale ultrasound analysis, color Doppler, power. A diagnosis of ocular melanoma can lead to grave outcomes, including enucleation and systemic spread. Considering the potential progression of this condition, it is important for a practitioner to. Melanoma is the sixth most common cancer in men and women and the second most common cancer in women ages 20 to 29 in the United States. Based on the most recent US data, there will be about 178,560 new cases of melanoma in 2018: 87,290 in situ (noninvasive) and 91,270 invasive Differential diagnosis of subungual melanoma from a surgical point of view Differential diagnosis of subungual melanoma from a surgical point of view Shukla, V. K.; Hughes, L. E. 1989-11-01 00:00:00 Subungual lesions referred to a surgical unit over a 17-year period have been reviewed to assess problems of differential diagnosis and management of suspected subungual melanoma

For melanoma, a biopsy of the suspicious skin area, called a lesion, is the only sure way for the doctor to know if it is cancer. In a biopsy, the doctor takes a small sample of tissue for testing in a laboratory. The doctor may suggest other tests that will help make a diagnosis and determine the overall stage of the melanoma Differential diagnoses: Subungual hematoma refers to a collection of blood within the nail plate or nail bed, often secondary to trauma. It could resemble subungual melanoma, with red-brown to brown-black discoloration. It typically migrates distally and spontaneously resolves with time, unlike subungual melanoma The diagnosis is challenging and often delayed (average depth at the time of diagnosis is 3.5-4.7 mm). Therefore, it can carry significant mortality and morbidity. The vast majority of nail melanomas arise in the nail matrix. Melanoma arising from the nail bed is rare. Two-thirds of cases of nail melanoma present as longitudinal melanonychia.

The risk is high as there is a family history of melanoma, sun exposure due to social activity and fair skin. A skin biopsy can be ordered to identify the diagnosis (Colyar, 2015). Skin cancers can start at the top layer of the skin and melanoma can develop anywhere but most commonly on the trunk, legs, face and neck (American Cancer Society. Clinical value of diascopy and other non-invasive techniques on differential diagnosis algorithms of oral pigmentations: A systematic review diagnosis of malignant melanoma and pigmented skin lesions, magnified or unmagnified diascopy is someti- Smoker´s melanosis Oral melanotic macule Endocrine disorders Addison´s diseas

Differential Diagnosis. Melanoma; Cellular blue nevus; Malignant blue nevus; PEComa; Paraganglioma-like dermal melanocytic tumor; Epithelioid leiomyosarcoma; Malignant peripheral nerve sheath tumor; Synovial sarcoma; Paraganglioma; The first five entities are either melanocytic or HMB45 positive and thus may be confused with clear cell sarcom Smokers melanosis Diffuse melanosis of anterior facial maxillary & mandibular gingivae , buccal mucosa , lateral tongue , palate & floor of mouth occasionally seen among cigarette smokers. Pigmented areas are brown , flat & irregular. Melanin synthesis is stimuylated by tobbaco smoke products. Heat of smoke may stimulate pigmentation The differential diagnosis consists of melanosis, nevus, pigmented Bowen's disease, and melanoma. Clinicians should take into account that melanosis is much more frequent than the other entities. Again, if the lesions are multiple, then the diagnosis of melanosis is much more likely than any other Idiopathic guttate hypomelanosis (IGH) is a common benign skin condition. It appears as multiple round or oval macules of depigmentation or hypopigmentation, mostly over the upper or lower.

Differential diagnosis Dermatology Educatio

Abstract. Over 90% of oral cancers are squamous cell carcinomas (OSCCs) which are of epithelial origin. Other types of malignancies account for the small remaining 10%. In this chapter, we describe the clinical characteristics of early- and advanced-stage OSCC and also consider the differential diagnosis of early-stage OSCC Neck lumps are a common presentation in the general population, presenting in both children and adults, and have a wide range of potential differential diagnoses. In this article, we shall discuss the differentials, investigations, and management of a patient presenting with a neck lump

Differential diagnosis of heavily pigmented melanocytic

Melanosis Coli Diagnosis Colonoscopy. Colonoscopy is a procedure that enables an examiner (usually a gastroenterologist) to evaluate the inside of the colon (large intestine or large bowel). The colonoscope is a four-foot long, flexible tube about the thickness of a finger with a camera and a source of light at its tip We discuss diagnosis and differential diagnosis together with implications for patient management, covering low-grade appendiceal mucinous neoplasms, high-grade appendiceal mucinous neoplasms, serrated polyps, adenomas and adenocarcinomas. We do not cover goblet cell tumours or neuroendocrine neoplasms in this paper Please use one of the following formats to cite this article in your essay, paper or report: APA. Thomas, Liji. (2019, February 26). Dermatofibroma Diagnosis and Differential Diagnosis The diagnosis is readily made in the great majority of cases, they are extremely common in the elderly, however, given their high variability in clinical and dermoscopic presentation they may be at times misdiagnosed, mimicking melanoma, squamous cell carcinoma and basal cell carcinoma. 4,5 On the other hand, melanoma may mimic SK clinically. Discussion. BCC and TFI can be confused both clinically and histologically. Differential diagnosis for TFI can be made based on clinical appearance with BCC, nevi, actinic keratosis, trichoepithelioma, inverted follicular keratosis, seborrheic keratosis, warts [7-10] and based on histopathological aspect with BCC, trichilemmoma, clear cell seborrheic keratosis [9-11]

Pathology Outlines - Melanosi

Develop a differential diagnosis of lymphadenopathy. Determine whether lymphadenopathy is localized or generalized. Consider the general differential with each presentation, utilizing history and clinical evaluation to guide you. Proceed to directed evaluation based on the differential A 21-year-old woman who had a history of stage IV melanoma with metastases to differential diagnoses, confirmatory laboratory testing, imaging, and medical and surgical management of hypercalce - mia are described in the patient with cancer. A history of smoking and exposure to other carcinogens, such as alcohol abuse an

Every day one disease Smoker's Melanosis PDF » Free PDF

Diagnosis and Management of Malignant Melanoma - American

There have been no associations demonstrated with smoking or alcohol. Epidemiology. LM/LMM is the third most common subtype of melanoma (behind SSM and NM), comprising 4 to 15% of all melanomas and 10 to 26% of melanomas on the head and neck. The mean age of diagnosis is 66-72 years, compared to 45 to 57 years for other melanoma subtypes Differential diagnoses. The differential diagnoses for a patient presenting with a subungual lesion are broad. Lesions can be divided into melanocytic and non-melanocytic. They can also be categorised as neoplastic, traumatic, infective, systemic and drug-induced. Figure 2 illustrates the clinical appearance of some common differentials. Figure 2 Adrenal Tumor: Symptoms and Differential Diagnosis An incidentally discovered adrenal tumor is also called incidentaloma. 80% of incidentalomas have no hormone production and are without clinical significance. In 20%, treatment is necessary because of hormonal activity or tumor growth. Signs and Symptoms of Adrenal Tumor

Conjunctival and Corneal Tumors: Primary Acquired Melanosi

Cavitary pulmonary metastases are most commonly (70%) caused by squamous cell carcinoma, which may of the lung or head and neck 1,4,6 . Other primaries are varied and include: Cavitating pulmonary metastases have also been reported to develop after chemotherapy, thought to be secondary to tumor necrosis or a valve-effect on an adjacent bronchi. young patient presenting with amelanotic choroidal melanoma. Differential diagnoses, symptoms, clinical findings, ancillary tests, treatment options and prognosis for amelanotic choroidal melanoma are discussed. Recognition of the clinical manifestations of choroidal melanoma leads to an early diagnosis and timely initiation of treatment Melanoma Metastasis. Although T1-hyperintense lesions are typically benign, correlation with the appearance on other MR sequences and imaging modalities as well as with clinical history may suggest an alternative diagnosis. Melanoma metastases appear as well-circumscribed T1-hyperintense lesions because of the melanin or hemorrhage Smoking history Patient age Differential Diagnosis: Neoplastic Bronchioloalveolar CA Mesothelioma Small cell lung CA Non-small cell lung CA Colon CA (rectal) Melanoma Unknown primary Lymphomatoid granulomatosis Infectious Tuberculosis Histoplasmosis Coccidiomycosis CMV Bacterial pneumoni